Complement molecules are the immune proteins responsible for identifying bacteria, viruses, and other foreign invaders as they circulate through our bodies. Their function helps lymphocytes to locate ...

They measured the levels of the proteins C3, C4, CH50, and C3D, which are biomarkers of the complement system.

We are studying the role of the complement system in kidneys and brains during health and disease. Traditionally, major complement proteins were shown to be generated by the liver and are functional ...

Complement is deposited and microglia attack neurons that could otherwise recover their function. We found that B4Crry prevented microglial phagocytosis of these live neurons." ...

Beyond C3d's permanence, which would address the bioavailability problems facing systemic complement drugs, C3d proteins change shape slightly once affixed to cells, so a monoclonal antibody could ...

In more recent years, it has become well established that complement also plays a role in focusing the antibody arm of the adaptive immune system on an antigen which it has tagged with a C3 split ...

News & Views Published: 20 February 2011 In self-defense Piet Gros Nature Structural & Molecular Biology 18, 401–402 (2011) Cite this article ...

Michael M. Frank, Keith Joiner, Carl Hammer, The Function of Antibody and Complement in the Lysis of Bacteria, Reviews of Infectious Diseases, Vol. 9, Supplement 5. Perspectives on Bacterial ...

ADX-097, Q32 Bio's lead product candidate from its tissue-targeted complement inhibitor platform, is a humanized anti-C3d mAb fusion protein being evaluated for the treatment of patients with ...