Mechanistic insights are emerging into how long non-coding RNAs (lncRNAs) regulate gene expression by coordinating regulatory proteins, localizing to genomic loci and shaping nuclear organization.

This is a summary of: Chen, J. et al.Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Nature 631, 905–912 (2024).. The problem. Microtubules are fibres formed from the ...