In this paper, the maximum likelihood estimation of a general two-level structural equation model with an unbalanced design is formulated as a missing data problem by treating the latent random ...

A simple matrix formula is given for the observed information matrix when the EM algorithm is applied to categorical data with missing values. The formula requires only the design matrices, a matrix ...

Recently, TaqMan® assays have been developed for detection of genetic variation at gene level using primers and probes designed for genomic DNA sequences. The R package TaqGCN contains classes and ...