Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-15520-5 ...

Remarkably, transposable elements (TEs) are responsible for creating around 1/3 of all loop boundaries in the human and mouse genomes, and contribute up to 75% of loops unique to either species.

Until recently, little was known about how transposable elements contribute to gene regulation. These are little pieces of DNA that can replicate themselves and spread out in the genome. Although they ...

Similarly, IFN-β treatment also induced TE expression, as many TEs contain IFN-responsive sequences that are upregulated after the induction of IFNs. This led to a hypothesis that SARS-CoV-2 ...

Abstract: The ACE2 receptor is, so far, the best-known host factor for SARS-CoV-2 entry, but another essential element, the TMPRSS2 protease, has recently been identified. Here, we have analysed ...

Chiara Braconi, Nicola Valeri, Takayuki Kogure, Pierluigi Gasparini, Nianyuan Huang, Gerard J. Nuovo, Luigi Terracciano, Carlo M. Croce, Tushar Patel, Raymond L. White, Expression and functional role ...