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However, the defacto GUI framework for Python is Tkinter, a wrapper around Tk that is relatively simple to use. So, I elected to go with that.
Tkinter has several advantages for Python GUI development, including its ease of use, its cross-platform compatibility, and its ability to create simple and lightweight GUIs.
The Python program then asks for the com port it should be using for this session. The source package, including the code which runs on the microcontrollers, can be found at the project repository.