AlphaMissense works not by predicting the change in protein structure upon mutation, but by leveraging databases of related protein sequences and structural context of variants to produce a score.

Now that you have a solid foundation in Supervised Learning, we shift our attention to uncovering the hidden structure from unlabeled data ... and a Jupyter notebook lab/Peer Review to implement the ...

CEBRA is a machine-learning ... no structure is found. Our method performs substantially better in recovering the ground-truth data than do other dimensionality-reduction algorithms such as ...