Methods Study Design and Patients This post hoc, pooled analysis included ICI treatment–naïve patients with unresectable melanoma who received NIVO + IPI (NIVO 1 mg/kg + IPI 3 mg/kg, or NIVO 3 mg/kg + ...

We develop an efficient and effective implementation of the Newton-Raphson (NR) algorithm for estimating the parameters in mixed-effects models for repeated-measures data. We formulate the derivatives ...