The Florida Python Challenge is held annually to raise awareness of Burmese pythons, an invasive snake, and the damage it has inflicted on the Everglades.

2025 Florida Python Challenge starts July 11 The 2025 Florida Python Challenge — a 10-day event to remove invasive Burmese pythons — starts at 12:01 a.m. July 11 and ends at 5 p.m. July 20.