It's worth noting that neither of Roche's phase 3 trials – PERSEVERA in the first-line setting and LIDERA as adjuvant treatment – appear to have ESR1 enrichment built into the design.

Enhertu is already approved as a second-line or later therapy for HER2-positive breast cancer based on the results of the DESTINY-Breast03 trial, as well as several other indications, including HR ...