Abstract: For the obstacle-avoiding rectilinear Steiner minimal tree (OARSMT) problem, we present a Steiner-point-based algorithm that achieves the best practical performance among existing heuristics ...

Abstract: As the basic model for very large scale integration routing, the Steiner minimal tree (SMT) can be used in various practical problems, such as wire length optimization, congestion, and time ...

Piece-wise non-linear regression is a long-standing problem in the machine learning domain that has long plagued machine learning researchers. It is extremely difficult for users to determine the ...

Researchers at GSK also took a structure-based design approach to developing 3,5-dimethylisoxazole-based BET bromodomain inhibitors. Starting from 4-phenyl-3,5-dimethylisoxazole, it was shown that a ...