Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Patterns of receptor−ligand interaction can be conserved in functionally equivalent proteins even in the absence of sequence homology. Therefore, structural comparison of ligand-binding pockets and ...

Anomalies often occur in real-world information networks/graphs, such as malevolent users in online review networks and fake news in social media. When representing such structured network data as ...

Chain-of-Thought (CoT) Distillation. When faced with diverse graph data, language models may encounter new or unfamiliar patterns and structures. This distribution shift can pose challenges in ...

Alzheimer's disease (AD) is a highly inheritable neurological disorder, and brain imaging genetics (BIG) has become a rapidly advancing field for comprehensive understanding its pathogenesis. However, ...

Based on InfraNodus AI text analysis and visualization tool, this plugin visualizes the content of Obsidian vaults as a knowledge graph, retrieves the main topical clusters, most important ideas, and ...