In this paper, a novel modified optimization algorithm is presented, which combines Nelder-Mead (NM) method with a gradient-based approach. The well-known Nelder Mead optimization technique is widely ...

The mission to improve the widely used simplex-method algorithm showed instead why it works so well.

New hifiasm-ONT assembly method delivers high-quality, cost-efficient near T2T assemblies using standard Oxford Nanopore Simplex reads, broadening access to comprehensive genome assemblies across ...

Termination Criteria for NLPNMS Since the Nelder-Mead simplex algorithm does not use derivatives, no termination criteria are available that are based on the gradient of the objective function. When ...