The original Nelder-Mead algorithm cannot be used for general linear or nonlinear constraints, but in the unconstrained or boundary-constrained cases, it can be faster. It changes the shape of the ...

Since the Nelder-Mead simplex algorithm does not use derivatives, no termination criteria are available that are based on the gradient of the objective function. When the NLPNMS subroutine implements ...

If you think you're your own person, think again. While you have the ability to make what you think seem like independent decisions, the truth is that ...

OXFORD, England, April 18, 2025--A new paper, released this week on bioRxiv, introduces hifiasm-ONT, a breakthrough genome assembly algorithm that enables partially phased, near telomere-to-telomere ...