Communication between MySQL and Python is handled by a contributed module, presented below. MySQLmodule. Python makes MySQL queries through a special module designed by Joerg Senekowitsch. Of course, ...

If you still think MySQL is too entrenched to be moved from its spot as the number one, open-source DBMS, you might to look at what Wikipedia is doing.

No, that's not a misprint. The famed open-source developer has come out of retirement to join Microsoft Developer Division and continue his work on the Python language.