A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.

No longer a mere assistant who carries out the commands of DNA, RNA takes the lead in emerging therapeutics.

It presents space-efficient data structures for some specialized but practically significant cases. In particular, the methods take advantage of contiguous sequences of keys in the lexicon to yield a ...

UniProt-PDB mapper Quick mapping of UniProt sequences to PDB structures This script maps residue numbering and chains between a UniProt ID and a PDB structure. It can also find all structures or the ...

This paper proposes a novel surrogate model for genetic programming that estimates the fitness of each individual by using the tree structure similarity. In particular, the fitness of each individual ...

Optimising sequences for high structure prediction confidence runs the risk of generating adversarial examples for AF which are unlikely to be recombinantly expressed in E. coli or adopt the designed ...