Overall, the choice between VBA and Python for Excel automation depends on your specific needs. Even though it's outdated, ...

If approved, Excel users would be able to use Python scripts to interact with Excel documents, their data, and some of Excel's core functions, similar to how Excel currently supports VBA scripts.

Python and Excel can only really talk to each other through limited functions—xl() and =PY()—that can only return code results, not macros, VBA code, or other data, Microsoft claims.