Traditional methods, whether experimental or computational, have repeatedly fallen short, unable to fully bridge the gap between sequence, structure, and function at a meaningful scale. Confirmed ...

Protein threading involves comparing a target sequence andor a hidden Markov model Karplus (2009) against one or more protein structures to identify the best matching sequence-structure template pair.

Metal-binding proteins have the exceptional ability to facilitate long-range electron transport in nature. Despite recent progress, the sequence-structure–function relationships governing electron ...

MiRNA subcellular localizations (MSLs) are essential for uncovering and understanding miRNA functions in various biological processes. Several computational methods have been proposed for measuring ...

However, story structure is a helpful tool to keep you on track, no matter what the end result looks like. And one of the most often used (and reliable) structures is called Freytag’s Pyramid.

Every cell in your body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These cell-specific gene expression patterns, which ensure that a brain cell is ...

I had a query: is there a way to decode the embeddings into 3 d structure or pdb files? For instance, I extract the embeddings from 3 d structure or pdb files of protein sequences. Now I update the ...

In parallel, and only in wakefulness, VIP interneurons responded to the omission of the locally expected sound repeat at the sequence ending, thus providing a chunking signal potentially useful for ...

In their manuscript entitled "Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex", Jamali et al. provide evidence for cellular-level mechanisms in the ...

Resolving the sequence and structure of flexible biomolecules such as DNA is crucial to understanding their biological mechanisms and functions. Traditional structural biology methods remain ...