The 2H-1,2,3-triazole tautomer is the major form in aqueous solution. [6] It is a surprisingly stable structure compared to other organic compounds with three adjacent nitrogen atoms. However, …

1,2,3-Triazole is an unsaturated, aromatic, five-membered, π-excessive nitrogen heterocycle with a 6π electron ring system, comprised of three regular nitrogen and two carbon atoms with two …

Apr 25, 2022 · This article explores the chemistry, synthesis, and therapeutic applications of triazoles, a class of nitrogen-containing heterocyclic compounds with superior pharmacological …

1,2,3-Triazole is an unsaturated, aromatic, five-membered, π-excessive nitrogen heterocycle with a 6π electron ring system, comprised of three regular nitrogen and two carbon atoms with two …

Apr 22, 2021 · The replacements in 1, 2, 4-triazole ring frameworks have been concentrated well among these heterocycles, and countless their subordinates have been recorded for an …

Also, in the pyrrole type nitrogen, the N-H bond is weakly acidic, whereas pyridine nitrogen is basic and nucleophilic.38 In the structure of 1H-1,2,3-triazole the three adjacent nitrogen …

Areas covered: This review article addresses the unique properties of the1,2,3-triazole nucleus as an intriguing ring system in drug discovery while focusing on the most recent medicinal …

The triazole ring is a basic five-membered ring, which consists of two carbon and three nitrogen atoms, hence the name ‘Triazole.’ There are two types of triazoles based on the position of …

Apr 1, 2017 · 1,2,3-Triazole ring system has been a subject of intense research due to its versatile potential to interact with diverse biological systems. In recent years, many synthetic …

The 1,2,3-triazole ring does not appear among the typical carboxylic acid moiety isosteres. However, Pippione et al. [51] reported an interesting example in which the role of N …