The Biomass Objective Function - PMC - PubMed Central (PMC)
Here we, 1) discuss the computation of cellular yields and growth rates and how they differ, 2) outline the formulation of a detailed biomass objective function, and 3) review several studies …
Opportunities at the Interface of Network Science and Metabolic ...
Unlike FBA, in which the analysis depends on the choice of a specific objective function, network methods rely on the metabolic stoichiometry alone. Metabolic modularity is an area where …
Principles of optimal metabolic network operation - PMC
Jul 10, 2007 · Using reconstructed genome-scale metabolic models, the group of Palsson has shown on several occasions that a well suited guiding principle—the so-called ‘objective …
Metabolic network modeling with model organisms - PMC
Metabolic networks for multiple plant tissues were derived from the generic model and combined in an organism framework. FBA was done by minimizing photon usage as the objective …
Mapping the landscape of metabolic goals of a cell
May 23, 2016 · Genome-scale flux balance models of metabolism provide testable predictions of all metabolic rates in an organism, by assuming that the cell is optimizing a metabolic goal …
Metabolic Network - SpringerLink
Feb 10, 2021 · Objective Functions. FBA can be applied to predict the optimal growth rate. In such case, the objective function is a biomass objective function. Biomass objective function …
Metabolic Objectives and Trade-Offs: Inference and Applications
Feb 6, 2025 · Results: Recent advances in single-cell omics, metabolic modeling, and machine/deep learning methods have enabled the inference of cellular objectives at both the …
Predicting biological system objectives de novo from internal …
We present a novel method called Biological Objective Solution Search (BOSS) for the inference of an objective function of a biological system from its underlying network stoichiometry as well …
Metabolic network modeling with COBRA — Metabolic network …
objective: optlang.interface.Objective: Before introduction of the optlang based problems, this function returned the objective reactions as a list. With optlang, the objective is not limited a …
Mapping the landscape of metabolic goals of a cell - PMC
May 23, 2016 · Genome-scale flux balance models of metabolism provide testable predictions of all metabolic rates in an organism, by assuming that the cell is optimizing a metabolic goal …